Causes of chronic autoimmune thyroiditis
Hashimoto's thyroiditis, orlymphomatoid thyroiditis is an inflammatory disease of the thyroid autoimmune nature as in the human body produce antibodies and lymphocytes damaging its own thyroid cells. (Normally, antibodies are produced in human body only for a foreign substance).
The most common autoimmune thyroiditis occurs inpatients 40 to 50 years in women and ten times more often than men. This is the most common inflammatory disease of the thyroid gland. And lately autoimmune thyroiditis is suffering more and more young patients and children.
It is believed that autoimmune lymphomatoidthyroiditis has a hereditary nature. Relatives of patients with Hashimoto's thyroiditis frequent diabetes, various thyroid disorders. But to implement a genetic predisposition need additional adverse external factors. This respiratory viral diseases, chronic foci of infection in the tonsils, sinuses, teeth affected by caries.
Contribute to the development of autoimmune thyroiditislong uncontrolled intake of iodine-containing drugs, radiation effects. Under the influence of a provoking factor in the body are activated lymphocyte clones that trigger the reaction of formation of antibodies to their own cells. The result of this process is the damage the thyroid cells (thyrocytes). Thyroid from damaged cells in the blood falls follicles content: hormones destroyed parts of internal cells organelles, which in turn contribute to further formation of antibodies to thyroid cells. The process becomes cyclical.
The main symptoms of the disease
Hashimoto's thyroiditis is oftenlong runs without any clinical manifestations. The early signs include discomfort in the thyroid gland, feeling a lump in the throat when swallowing, feeling of pressure in the throat. Sometimes there is not strong pain in the thyroid gland, mainly at thyroid palpation. Some patients may complain of mild fatigue, joint pain.
If the patient has hyperthyroidism (due to a large ejection hormones in blood is damaged thyroid cells) the following report:
- trembling fingers
- acceleration of the heart rate
- increased blood pressure
Most state of hyperthyroidism occurs at the beginning ofdisease. Subsequently, thyroid function may be normal or reduced neskolgo (gipotiroz). Hypothyroidism usually occurs after 5-15 years of disease onset and the extent of its uslivaetsya under adverse conditions. In acute respiratory viral diseases, mental and physical overload, aggravation of various chronic diseases.
Depending on the clinical picture and the sizes of thyroid autoimmune chronic thyroiditis Hashimoto divided into shape:
- atrophic form
- hypertrophic form
When atrophic form of increased thyroidcancer does not happen. It occurs in most patients, but more often in the elderly and in young patients who underwent radiation exposure. Usually this form is clinically accompanied by a reduction in thyroid function (gipotiroz).
Hypertrophic form of autoimmune thyroiditisalways accompanied by an enlargement of the thyroid gland. The thyroid gland can be increased uniformly throughout the volume (diffuse hypertrophic form), or the presence of marked nodes (nodular form). Perhaps a combination of diffuse and nodular forms. Hypertrophic form of autoimmune thyroiditis thyrotoxicosis may be accompanied by the beginning of the disease, but most of the thyroid function is normal or reduced.