What is Isenko Cushing Syndrome? What are the symptoms of Isenko Cushing syndrome? How does the diagnosis and treatment of Isenko Cushing syndrome? Answers to these questions you will find in the article.
Content
Incenko Cushing Syndrome
This term is used to describe the symptom complex,
accompanying an increase in concentration in glucocorticoid organism
Gormons. In foreign literature, the syndrome is known called
Cushing syndrome.
Causes:
- Adrenal tumors (glucoster, glucandrostrometer).
- Lung tumors, bronchi, mediastinum, pancreas,
secreting adreno-cortico trop hormone (ACTH); that leads to
Development of Cushing's disease characterized by similar clinical
Symptoms.
It should be remembered that a whole series is combined under this title
Pathological conditions: an increase in secretion by hypophysome ACTH, illness
Cushing, adenoma or adrenal cancer and others. In addition, it follows
Find out a patient with signs of Cushing's syndrome, does he take
drugs containing glucocorticoids, for example, prednisone
(long-term reception of such drugs leads to the development of Cushing syndrome).
The manifestation of clinical symptoms of syndrome does not allow
Clearly divided patients with Cushing's disease from patients with adenoma
or adrenal cancer. However, more often in patients men with cancer
adrenal gland develops feminization (the appearance of female signs), and
Women - Virilization (Answering). Should also remember
The existence of Cushing's pseudo-syndrome, for example, in patients,
suffering from severe depression or alcoholism.
With the development of the disease due to the pathology of the adrenal glands
The emergence of symptoms is due to excessive secretion
glucocorticoid hormones, in particular, cortisol, adrenal glands.
Observed at any age, but more often at 20-40 years; Women are getting 10 times more often than men.
Symptoms of Isenko Cushing syndrome
Excessive fat deposition in the field of face, neck, torso. Face
becomes moon-like. The limbs are thin. Dry skin, thinned, on
Face and in the chest area - bugvo-blue color. There is a formation
finger tips, tip of nose, lips - acricyanosis. Clearly expressed
venous drawing («grid») on breasts and limbs, stretching stripes
(«Stretch marks») on the skin of the abdomen, hips, the inner surfaces of the hands.
It is often noted by the darkness of the skin, more often in places of friction. On the skin face,
LIFETING WOMEN IN EXCELLENT SUPPLY. Hell increased. Change
Skeleton, developing with insufficient calcium quantity:
Heavy current there are fractures of ribs, spine. Violation
carbohydrate exchanges up to the development of diabetes, bad
treatable. Possible mental violations: depression or
euphoria.
In blood tests: Reducing the concentration of potassium in the blood
varying severity; The number of erythrocytes, hemoglobin and
Cholesterol enlarged.
Distinguish light, moderate gravity and severe forms of the disease;
The flow may be progressive (the development of all symptoms for 6-12
Mon) and gradual (symptoms gradually grow within 3-10 years).
Diagnosis of Izhenko Cushing syndrome
- Determination of the content of cortisol in the urine and blood plasma; definition
Concentration in the blood plasma ACTH (the most reliably night increase).
- Then the source of high secretion of hormones is determined -
hypophies or adrenal glands: during pituitary adenoma - changes according to data
computer tomography skull or an increase in both adrenal glands, and
In the presence of an adrenal tumor, its image is visible on
the corresponding side according to CT data (computed tomography); Adrenal tumor also
diagnosed with scintigraphy.
- Diagnostic tests for eliminating tumors of adrenal cortex are samples with dexamethasone, metopiron.
Treatment of Isenko Cushing Syndrome
- Pathology pituitary - Surgical removal of pituitary.
In the presence of adrenal adenoma - surgical (removal of adenoma, including laparoscopic adrenal removal - Laparoscopic adrenalctomy). In seriously inflated, bilateral adrenalctomy; after
Operations develop chronic adrenal insufficiency that
requires constant replacement therapy.
- Laparoscopic adrenalctomy (la) - effective method
treatment of endocrine diseases due to pathology
adrenal glands and violation of the pituitary work promoting
Development of Cushing Syndrome. Today laparoscopic adrenalctomy
is a widespread operation in the world. Double-sided
Laparoscopic adrenalectomy gives good results when
inefficiency or lack of possibility of removal operation
pituitary.
- Under the adrenal cancer - the choice of treatment method is carried out
Individually. With a light and moderate course, the radiation is carried out
Therapy. In the absence of effect from radiation therapy, one is removed
Adrenal or conduct a course of cloak treatment (reduces synthesis
Hormones in the adrenal cortex) in combination with other drugs.
- Conservative therapy is aimed at compensation for protein
(retabolil), mineral (preparations of potassium, Veroshpiriron) and carbohydrate
(Sugarizing drugs in combination with insulin) exchange. Besides,
Prescribed, if necessary, reduced blood pressure drugs, diuretic
Means, heart glycosides (digoxin).
