Syndrome of disseminated intravascularcoagulation (DIC) is one of the most important general pathological phenomena, as there is a variety of diseases and pathological conditions:
- sepsis and viremia;
- all kinds of shock;
- traumatic surgical interventions;
- obstetric diseases;
- extensive burns;
- bone fractures;
- crush syndrome;
- destructive lesions of parenchymal organs;
- Acute intravascular hemolysis and cell count of white blood cells;
- systemic lupus erythematosus;
- nodular periarteritis;
- thrombotic thrombocytopenic purpura;
- hemorrhagic vasculitis;
- uremic hemolytic syndrome;
- bites of poisonous snakes;
- massive transfusion, etc.
On the diagnosis of disseminated intravascular coagulation
For all forms of DIC is characterized by a succession of phases and hypercoagulable anticoagulation (ie, high and low blood coagulation phase).
hypercoagulable phase can be short and quickend widespread intravascular coagulation, and hypercoagulable shock. In other cases, it develops slowly, discreetly, and not always recognized in time.
Initial laboratory diagnosis is performedusing simple laboratory tests (total blood coagulation time, fibrinogen - a special protein produced in the liver and is converted to insoluble fibrin - the basis of the clot in blood coagulation and others.). However, increased blood clotting (hypercoagulability) are best determined by special standardized tests.
Important patterns flow DIC is that when it is depleted not only blood coagulation, and anticoagulant mechanisms.
Because of this, their own clots are removed from the vessels poorly, while input from the outside to quickly lyse clots.
DIC may be acute, subacute, protracted and recurrent course, the latter is characterized by multiple repetition of hyper- and anticoagulation phases.
If a doctor diagnosis Guideprimary pathogenetic mechanism of development of DIC, the clinical picture (bleeding, renal failure, lung and others.) and data integrated laboratory examination.