Cushing's syndrome (Cushing's syndrome) includes a group of diseases wherein
that chronic long-term effects on the body occurs
excessive amounts of adrenal hormones, regardless of
the reasons which caused increasing amounts of these hormones in the blood.
The cause of Cushing's syndrome can be different states. More often
Cushing's syndrome (excess formation of the cortex hormones
adrenal glands) is due to increased production
adrenocorticotropic hormone pituitary (Cushing's disease). This
hormone can be produced microadenomas pituitary or ectopic
(Not located in the usual place) kortikotropinomy. ectopic
malignant kortikotropinomy can be located in the bronchi, the testes,
Less Cushing's syndrome occurs when the primary lesion of the cortex
adrenal (benign or malignant tumor cortex
adrenal gland, adrenal hyperplasia). Hormonally active
a tumor of the adrenal cortex called corticosteroma. It produces a
blood glucocorticoid excess amount. Thus for
excessive amounts of glucocorticoids in the blood reduces the amount
adrenocorticotropic hormone of pituitary and adrenal rest tissue
undergoes atrophic changes.
Cushing's syndrome can occur in the treatment of various
diseases with adrenal cortex hormones (glucocorticoids)
if a drug overdose. Occasionally there are unusual
Cushing's syndrome, caused by eating food or alcoholic
Manifestations of Cushing's syndrome
When Cushing's syndrome manifestations of the same type occur.
Disturbed metabolism of proteins, fats and carbohydrates. Activated protein breakdown,
produced an excessive amount of free fat in blood rises
the amount of glucose in the patient's blood, which can lead to the development
Manifestations of Cushing's disease are caused by excessive secretion of adrenal hormones, especially glucocorticoids.
- The earliest sign of the disease is obesity, a typical
the deposition of fat in the face, neck, abdomen, chest. Face
thus looks round, lunoobraznym.
- On the cheeks appears purple glow.
cause increased appetite and alter metabolism, increasing
blood glucose levels and increased fat deposition.
- Conversely limbs become thin due to the decrease in muscle mass.
the skin in the abdomen, shoulders, buttocks and thighs appear
purple-bluish band stretching - stretch marks. This is the result of stretching
skin with excess deposition of fat and protein metabolism disorders, because of the
which thins the skin and is easily stretched.
- The skin appears acne rash.
- Wounds and cuts heal slowly.
areas of friction in the region of the collar around the neck, the abdomen, elbows
there is increase in staining of the skin. In these places,
Melanin is deposited, the amount of which increases with
the amount of adrenocorticotropic hormone.
In women, there is hirsutism (excessive body hair). appear
the hair on the upper lip, chin, chest. Excess hair growth
women due to increased production of male sex hormones
androgens by the adrenal cortex, that women also causes disturbances
In men, there is impotence.
Initially, there is periodic, then the constant improvement
blood pressure. Gradually developing bone loss - osteoporosis, which is manifested first pains in bones and joints,
then you may experience spontaneous broken ribs and limbs. Excess
glyukortikoidov is a violation of the formation of protein-based
bones and increases calcium release from the bone.
Patients complain of fatigue, headaches, weight gain.
Sometimes disease patients with hypercortisolism violations occur
psyche. There are depression, various sleep disorders, psychosis.
Treatment of Cushing's syndrome
The goal of treatment - normal levels of hormones in the adrenal cortex
blood. Used drugs reduce the production of hormones in the cortex
adrenal - Nizoral, Mam, metapyron - for a long
Symptomatic treatment aimed at correcting
disorders of protein and carbohydrate metabolism, normalize level
blood pressure, heart failure treatment. In the presence of
corticosteroma patient, unilateral removal is carried out
adrenal gland (unilateral adrenalectomy).