The forms of amyloidosis

Content

  • The forms of the organism defeat in amyloidosis
  • Features of primary amyloidosis
  • Features of secondary amyloidosis
  • Family amyloidosis
  • Beta-2 microglobulin amyloidosis
  • Local amyloidosis



  • The forms of the organism defeat in amyloidosis

    The forms of amyloidosisAmyloidosis - a group of diseases thatarise due to deposition of certain proteins (proteins) called amyloid in various body tissues. Amyloid protein is deposited in localized areas and not to harm body tissues. This form of amyloidosis is called localized amyloidosis.

    Amyloidosis, which has an effect on tissuethe whole organism, called a general amyloidosis. Total amyloidosis can cause serious changes that may occur in reality in any organ of the body.

    Amyloidosis can occur independently or"Second" as a result of another disease, including complex myeloma, chronic infections (such as tuberculosis or osteomyelitis), or chronic inflammatory diseases (such as rheumatoid arthritis and ankylosing spondylitis). Eventually amyloidosis may also spread to a certain body part. This localized form of amyloidosis does not common complications of other body parts. The protein that is deposited in the brains of patients with Alzheimer's disease is a form of amyloid.

    Total Amyloidosis is classified into three maintypes, which differ significantly from each other. There is a code consisting of two letters, which begins with the letter A (amyloidosis). The second letter code denotes a protein that is deposited in the tissues of a particular type of amyloidosis. Currently distinguish primary amyloidosis (AL), secondary amyloidosis (AA) and hereditary (ATTR).

    In addition, other forms of amyloidosis include beta-2 microglobulin amyloidosis and localized amyloidosis.



    Features of primary amyloidosis

    Primary amyloidosis or AL, occurswhen a special bone marrow cell (plasma cell) suddenly develops an increased portion of the protein, which is called the light chain. The deposits in the tissues of people with primary amyloidosis are AL proteins. Primary amyloidosis can occur together with a cancer of plasma cells of bone marrow, a complex called myeloma. Primary amyloidosis is not associated with other diseases, but it is - a disease that usually requires chemotherapy. Some researchers have shown favor stem cell transplantation as a treatment of primary amyloidosis.



    Features of secondary amyloidosis

    When amyloidosis occurs secondary toother diseases such as, for example, complex myeloma, chronic infections (e.g., osteomyelitis, or tuberculosis) or chronic inflammatory diseases (e.g., rheumatoid arthritis and ankylosing spondylitis), such a state is called secondary or AA amyloidosis. Fabric amyloid that is deposited in secondary amyloidosis, protein called AA. Treatment of people with secondary amyloidosis is directed for the treatment of the root cause of the disease of each individual patient.



    Family amyloidosis

    Family amyloidosis, or ATTR is a rarea form of hereditary amyloidosis. Amyloid formation in hereditary amyloidosis transthyretin protein consists of or TTP that is formed in the liver. Family amyloidosis is called autosomal dominant in genetic terminology. This means that children born to parents with amyloidosis, there is a 50% chance of inheriting the disease.



    Beta-2 microglobulin amyloidosis

    Beta-2 microglobulin amyloidosis occurswhen in patients undergoing dialysis procedures begin amyloid deposits. Amyloid deposits are composed of beta-2 microglobulin protein and are often found near the joints.



    Local amyloidosis

    Many forms of amyloidosis are localresult of amyloid deposits in specific areas of the body, and are different from the common forms of amyloidosis, which are found throughout the body. Local amyloidosis deposits are found in the brain of Alzheimer's disease. With age, amyloid can be locally produced and deposited in different tissues of the body.

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