Overview of the disease
Under the term «Miasthenia» Nervous muscular pathology is hidden, which is characterized by muscle weakness and constant fatigue, increasing when performing any works. The forces are returned after a person rested, but quite briefly. For the first time, the disease described in 1672 English Dr. Thomas Willis.
About the causes of occurrence
There is opinion among doctors that this is a genetic disease. However, at the gene level, it is not yet sufficiently studied. Scientists explore the mutation of the gene responsible for the activities of neuromuscular synapses. Already revealed two mechanisms for the development of myasthenia:
- An autoimmune damage of the thymus (so called the fork iron), in which the neuromuscular transmission is disturbed. There is a decrease in the synthesis of acetylcholine, and the cholinesterase becomes more active.
- Biochemical disorders in the zone of myioneral synapses that are associated with the change in the function of the hypothalamus, the driving attachment to the pathprocession of the fork gland.
What can run these negative processes?
- Disorders of immune links and organism processes, as a result of which antibodies begin to form antibodies to their own cells of the organism, protruding then against the acetylcholine receptors of synapses (their postsynaptic membranes). Normally, these neuromuscular compounds must transmit pulses from the neuros to the muscle due to biochemical reactions in which the acetylcholine mediator is involved. During myasthenia, the correct transmission mechanism of the nerve pulse to the muscle is hampered or becomes almost impossible.
- Colds.
- Stress.
- Excessive Muscle Loads.
How the disease is manifested?
After inspection, the following methods help the doctor's diagnosis:
- Electromiography - allows you to observe my asthenic reaction.
- Prezero test.
- Clinical inspection that allows you to understand the reversibility of miasthenic changes after the introduction of prozerne.
- The immunological test is necessary to determine the titer of the organism antibodies to acetylcholine receptors, identifying the tumor of the fork gland (it is called tymoma).
- CT of the Front Media.
Recommendations for treatment
The main drugs used in Miasthenia are Kalimin, Galanamin, Prezero. They belong to the group of anticholinesterase products. Patients take them years, clearly following the dosage of the doctor, its recommendations relating to the Time Time.
To increase the effect of these funds, potassium preparations are prescribed (potassium chloride, potassium-normon).
In serious cases, doctors prescribe hormone therapy (according to the prednisone or methipred) and cytostatics.
If a tumor of a fork gland is found, surgery (timectomy) is carried out.
During my asthenic crisis, the patient is in intensive care. It makes plasmapheresis, artificial ventilation of lungs, immunoglobulins are introduced, prozero ..
Suffering Miastenia can not be under direct sunlight (sunbathing), engage in heavy labor, taking tranquilizers, Panangin, magnesium preparations, neuroleptics, many Antibiotics, Miorolaxanta. Therefore, before taking some kind of drug, not appointed by a neurologist, it is necessary to clarify the doctor if it does not harm health. Such patients can be resting and recovery in profile sanatoriums. They are in Mordovia, Tatarstan, Buryatia, Altai, Stavropol, Krasnodar Territory ..
If the disease is rapidly progressing, it leads to disability. To preserve as long as possible quality of life, ability to work, it is necessary to constantly observe the neurologist, regularly fulfill all its prescriptions and recommendations. Medicines for such patients are released from pharmacy institutions for free, upon presentation of a properly decorated recipe.
