Deciphering tests for anti HCV
The intrusion into the body of hepatitis C virusgeneration of immunity is responsible immunoglobulin antibody (anti-HCV). They include structural (core) and non-structural proteins (NS3, NS4, NS5). Information about antibody indicators provide insight on the viral load, the activity of the virus and the risk of its transition to a chronic form, as well as on the state of the liver.
The presence of total anti-HCV investigated in everyone tested for hepatitis C, a diagnosis is carried out in the early stages.
Antibodies core IgG appear a halfmonths after infection, and the maximum concentration is necessary for six months after infection. class G immunoglobulin is typical for chronic forms of hepatitis C is detected for life after suffering a once HCV.
IgM antibodies are detected six months afterinfection, and their concentration increases rapidly. This class is considered to be a marker of acute forms of HCV: his figures are falling at the end of an acute attack, and increase again when the reactivation of the virus.
NS3 antibodies determined in the early stagesthe formation of antibodies. Their high concentration of titles and talk about the process of acute HCV. The duration of this condition often leads to chronic hepatitis.
Antibodies NS4 and NS5 reduced after recovery. High titers of antibodies NS4 indicate possible liver damage and duration of infection. The increased concentration of anti-NS5 - the presence of HCV RNA and chronic virus.
Indicators for decoding anti HCV:
- IgM +, core IgG +, (NS and IgG) -, RNA (= RNA) HCV + → acute form of hepatitis C;
- IgM +, core IgG +, (NS and IgG) +, RNA (= RNA) HCV + → chronic form of hepatitis C in the reactivation phase;
- IgM-, core IgG +, (NS and IgG) +, RNA (= RNA) HCV- → chronic form of hepatitis C in the latent phase;
- IgM-, core IgG +, (NS and IgG) +/-, RNA (= RNA) HCV- → recovery after acute hepatitis C or chronic hepatitis C in a latent form.
For more specific decoding analysis, refer to the infectious diseases doctor and hepatologist.