endocrinological practice syndrome with lack of sexual function
gland is regarded as a pathological condition caused by
violation generation gonadotropin and sex hormones. As a rule, this
hormonal imbalance is accompanied by underdevelopment of domestic
external genitalia, and all the signs that lead to sex
According to the classification of female hypogonadism, hormone release two options:
- hypergonadotrophic - developed with increased activity steroidoprodutsiruyuschih pituitary cells;
- hypogonadotropic - characterized by a pronounced decline in the synthesis of FSH and luteinizing hormone.
In addition, depending on the moment of occurrence of pathological processes are distinguished:
- primary version - formed in utero infant's life;
- Secondary - occurs under the influence of unfavorable factors after birth, when formed genitalia.
Ovarian failure, combined
with primary amenorrhea, when the age of puberty
no menstruation begins - the main symptoms of hypogonadism female.
What kind of pathological symptoms should alert attentive mother
teenage girl aged 12-14 years? First, a complete
the absence of a menstrual cycle, even after the period of sexual
maturing girls breasts are not developed, pubic
and armpits practically absent body hair. Figure
girl, her gait, high growth, body proportions eunuchoid at first
look reminiscent of a young man or teenager.
hypogonadism, treatment which starts with the identification of
disease, usually caused by congenital hypoplasia of the ovaries.
Turner's syndrome is an example of hypergonadotrophic
state, with typical chromosomal changes cause
clinical disease. Patients with this syndrome
characterized by short stature, short neck with typical alar
folds, bending elbows, multiple bone
deformations, malformations of the heart and blood vessels. In the general survey
It notes that the breasts are not developed, the nipple is fully retracted,
there is no typical body hair, vaginal study confirms
underdevelopment of the internal organs, there is "infantile" uterus and ovaries
a pancake tyazhistyh formations. Genetic and laboratory
Survey confirms the absence of sex chromatin and a high
levels of gonadotropins.
Hypergonadotrophic hypogonadism, treatment at a syndrome
Turner suggests cyclic hormone therapy with
assistance of estrogens and progestogens, is subject to compulsory dispensary
Observation. This drug treatment helps shape
secondary sexual characteristics, the feeling of sexual desire and libido.
Hypogonadotropic hypogonadism is most often caused by defeat
hypothalamic-pituitary or testicular tissue. Failure
ovaries may be caused by an autoimmune process, exposure
critical dose of ionizing radiation, surgical removal
ovaries, ovarian tumors androgensinteziruyuschimi. these endocrine
diseases such as Cushing's syndrome, acromegaly, hypothyroidism,
Graves' disease, Addison's disease, congenital adrenal hyperplasia
It can also be the cause of reduction of gonadotropic pituitary function.
The main manifestations of hypogonadotropic hypogonadism should include
menstrual disorders and infertility. A woman worries
menstrual irregularities, which, depending on the level of hormone
failure can come with delays of up to 2-3 months or more.
With the progression of hypogonadism occurs amenorrhea or complete
the absence of menstruation and infertility.
Treatment of secondary hypogonadism form begins with the identification of the causative
factor, which served as the basis for the development of the syndrome. Correction of hormonal
changes helps restore menstrual cycles and overcome