What is Addison's disease
Addison disease amazing on average 4 of The function of the adrenal glands is also suppressed in people receiving With severe dehydration and low level of sodium, blood volume decreases, and in severe cases, shock can develop.
Corticosteroid shortages also increases sensitivity to To compensate for corticosteroid shortages, hypophyses produces
every 100,000 people. She can start at any age and
meets in men and women approximately with the same frequency. In 30%
cases of Addison disease - secondary illness and arises as
Consequence of malignant tumor, amyloido, tuberculosis, etc. In 70%
Cases The reason for this state is definitely not known, but scientists
It is assumed that the adrenal glands are destroyed as a result of autoimmune
Corticosteroids, for example prednisolone. Cancellation of corticosteroids must
Gradually occur, with a slow dose reduction. When reception
Corticosteroids stop suddenly after a long (month or more)
therapies, adrenal glands for several weeks or even months
turn out to be unable to produce corticosteroids in sufficient
Some other medicines, such as antifungal drug
ketoconazole (nipped, oronazole) can also block natural
Corticosteroid generation, leading to their deficiency.
Corticosteroid shortages leads to many violations. One of
they are that the body displays too much sodium and
Too little potassium, resulting in sodium content in blood
decreases, and the content of potassium, respectively, grows. Kidney ne
able to concentrate urine, so when a person with a deficit
Corticosteroids drinks too much water or loses too much
sodium amount, blood sodium level decreases. failure to
Concentrate urine ultimately causes abundant urinary and
insulin - hormone, normal circulating in the blood, so the content
Sugar in the blood can fall sharply. With a shortage of corticosteroids in
The body is disturbed by the formation of carbohydrates from proteins, rises
susceptibility to infections and slow down wound healing. Fall
Muscle tone, including the tone of the heart muscle, and the power of heart
more adrenocorticotropic hormone, which is normal
Stimulates adrenal glands. Takakadrenocorticotropic hormone
affects the production of melanin, people with Addison's disease often
Excessive skin pigmentation and mouth mucosa develop,
usually in the form of spots. This happens in people with dark skin, although in
this case change coloring is difficult to recognize. Excessive
Pigmentation does not occur in adrenal insufficiency,
caused by damage pituitary or hypothalamus when the main
Violations are associated with a deficiency of adrenocorticotropic hormone.
The function of the adrenal glands is also suppressed in people receiving
With severe dehydration and low level of sodium, blood volume decreases, and in severe cases, shock can develop.
Corticosteroid shortages also increases sensitivity to
To compensate for corticosteroid shortages, hypophyses produces
What are the symptoms of Addison's disease If the disease is not treated, severe abdominal pain may occur,
The earliest symptoms of Addison's disease are weakness, fatigue and
dizziness when you get up from the position lying or sitting. The skin darkens I
It becomes like a flubble, and the dark color appears on
open and in closed parts of the body. On the skin of his forehead, faces and shoulders can
come black freckles; Characteristic blue-black coloring of the skin
Around the nipples, lips, mouth, rectum, scrotum or vagina. Sick
losing weight and lose appetite; Development is developing. Pains appear in
muscles, nausea, vomiting and diarrhea. Many become very sensitive
To cold. If the disease proceeds not in very hard form, symptoms
manifest only during stress.
There is a pronounced weakness, arterial decreases significantly
pressure, renal failure and shock, especially in
Stressful situations - during injury, operation or severe infection. IN
very soon may occur death.
If the disease is not treated, severe abdominal pain may occur,
Diagnosis of Addison Disease Blood tests can identify the lack of corticosteroids, especially
Since the symptoms are developing slowly and at first, unauthorized, to
No laboratory analysis allows you to put with confidence
Diagnosis, doctors often do not recognize Addison's disease in the initial stage.
Sometimes severe stress, such as an accident, operation or
serious illness, makes the symptoms more obvious and provoke
Cortisol, as well as low sodium content and high potassium.
Results of blood analysis per nitrogen level of urea and creatinine usually
indicate a reduction in the kidney function. Definition of content
Corticosteroids are carried out after administration of adrenocorticotropic
hormone (stimulation test), which helps the doctor to distinguish
Insufficiency of adrenal function from lack of function
pituitary. In the latter case, another analysis is required - after injection
remiocticotropic hormone rilizing factor to see, not
Is the condition of the patient with an insufficient function of the hypothalamus.
Blood tests can identify the lack of corticosteroids, especially
Treatment of Addison's disease
Regardless of the cause of Addison's disease represents a threat to life, and in
First of all, the patient is prescribed Courtfather. Treatment usually
start with prednisic-wing intake. If the patient's condition
Heavy, first introduced intravenously hydrocortisone (SOLU-CORTEF,
hydrocortisone sodium succinate) and then moving to tablets
As a rule, people with Addison's disease also need
Reception 1 or 2 Fludrocortisone Tablets (Cortinef, Floerinf) daily,
To restore normal excretion from sodium and potassium organism.
The flortison dose is gradually reduced, subsequently some people
can generally cancel this drug, but prednisone they should
take one's day. When the body is subject to stress,
Especially in case of severe illness, large doses may be needed
Prednisolone. Although patients are forced to continue treatment throughout
life, on the duration of life it usually does not affect.