Pituitary dwarfism - a disease characterized by delayed growth and physical development. Karlikov believe the growth of adult men below 130 cm, adult women - below 120 cm.
- Decrease or loss of growth hormone of pituitary function (pituitary production of growth hormone - STH)
- biologically inactive growth hormone (defect hormone, growth hormone are not able to regulate tissue growth that does not perform its function orginizme)
- violation of the sensitivity of peripheral tissues to growth hormone (disruption of cell receptors that recognize the hormone and transmit information about his admission in a cell)
Against the backdrop of a sharp increase in the backlog, delaysgrowth rate and bone maturation of the child has a normal body proportions. Due to the underdevelopment of the facial bones of the skull features small face, the bridge sinks, typical of "doll" face. The hair is thin, high voice. Often there is an excess of body weight. Boys tend to be micropenis. Delayed sexual development. In pituitary dwarfism need lifelong replacement therapy with human growth hormone.
The main method of pathogenetic therapy dwarfism- The introduction of human growth hormone (HGH). It is necessary to observe two main principles: to achieve normal levels of human growth and development and to extend the height of the individual as long as possible.
An effective treatment for dwarfism isdrug therapy with anabolic steroids (hormones that stimulate the development and growth of the human body tissues); they are used for several years with the gradual replacement of the less active drugs more active. The course of treatment intermittent: the period of "rest" is about half the duration of treatment; when addiction show breaks up to 4-6 months. Apply metilandrostendiol, methandrostenolone (Dianabol, Nerobolum) fenobolin (Nerobolum) retabolil. dosing principle gradual increase doses, ranging from the minimum effective doses. Anabolic steroids are used as long as possible the effect of growth (up to 16-18 years and sometimes more durable).
Forecast for life with genetic forms of dwarfismfavorable, in the presence of brain lesions (trauma, tumor) it is determined by the underlying disease. It is advisable to begin treatment within 5-7 years.
Implemented lifelong observation of the endocrinologist.
Importance has adequate nutrition, restorative therapy vitamins and biostimulants, and zinc preparations.
With concomitant hypothyroidism (lack ofthyroid hormones) at the same time prescribe medications thyroid hormones (thyroid Gomonov). Girls over 16 years prescribed small doses of sex hormones (estrogen, chorionic gonadotropin, pregnin, progesterone). Patients with disproportionate dwarfism physique with systemic skeletal pathology hormonal treatment and not be in need of supervision of orthopedic trauma.
When mental disorders shown symptomatic correcting means (sedatives, antidepressants).