Meet myasthenia gravis

Content

  • Where does myasthenia gravis
  • Myasthenia gravis: what happens
  • Such different myasthenia gravis
  • Diagnosis of myasthenia gravis
  • Medication or surgery

  • Sometimes a constant weakness and fatigueIt is a sign of a serious disease. Therefore, before you write off your fortune on fashionable in our time "chronic fatigue syndrome", it is better to consult a doctor and undergo all the necessary research. You may need not only to drug treatment, and surgery.

    Where does myasthenia gravis

    Meet myasthenia gravisMyasthenia gravis - a neuromuscular disease characterized by muscle weakness and constant fatigue, which intensified after physical exertion and decreases with rest.

    In the blood serum of patients with myasthenia areantibodies to the protein in skeletal muscle, epithelial cells of the thymus gland, and receptors that can produce acetylcholine (a substance with which transmit nerve stimulation), which is a sign of autoimmune aggression - the development of antibodies against its own tissues (normal antibodies are produced to protect against external influences; gluing with antigen, such as bacteria or viruses, they are precipitated and removed from the body).

    In myasthenia gravis often detected proliferation orvarious tumors of the thymus, which is responsible for the formation and development of cellular immunity. Myasthenia gravis can appear immediately, provoking factors are stress, respiratory diseases, immune disorders, high physical activity, etc.


    Myasthenia gravis: what happens

    Onset of the disease in most casesIt refers to 20-30 years, but sometimes begins in childhood and is manifested after 50 years. Women suffer more often than men, but in the elderly often suffer from men.

    The disease is often subacute orchronic. There are oculomotor disturbances in the form of the omission of the century (ptosis), double vision (diplopia), disorders of the pharynx and larynx muscles (difficulty in swallowing, speech and voice disorders), general weakness and fatigue. This phenomenon manifests widespread muscle fatigue during muscular load, which takes place during the holidays.

    One of the symptoms may be a violationactivity of the endocrine glands: increased function of the thyroid gland, adrenal insufficiency, which in turn can cause a deficiency in potassium, which is needed for the heart muscle - there are cardiovascular disorders.


    Such different myasthenia gravis

    distinguish progressive form of the current,myasthenic episodes (short-time and long-term remission of the disorder - condition is worsening) and myasthenic state (continued long).

    In childhood myasthenia gravis may occur as a congenital, early childhood and juvenile forms.

    Congenital form appears weak perturbationfetus after birth - a weak cry, difficulty in sucking and swallowing. After 4-6 weeks, these effects disappear. Early children's form is characterized by a mild course and mostly local symptoms (one muscle group defeat). The juvenile form starts at 11-16 years of age and manifests common disorders.

    myasthenic crisis

    Under the influence of various external factors(Infections, exercise, stress), violations of the endocrine system can come sharp deterioration - myasthenic crisis. The crisis manifested the rapid spread of myasthenic disorders with significant disorders of the eye muscles, muscles of the pharynx and larynx. The patients can not swallow, not only food but also saliva, there are shortness of breath, anxiety, alternating with apathy. Sometimes 10-20 minutes may develop a serious condition with loss of consciousness.


    Diagnosis of myasthenia gravis

    Myasthenia gravis is a rare disease, so is not always correct and timely diagnostitruetsya. The criteria for a correct diagnosis are:
    • typical symptoms of myasthenia gravis;
    • pharmacological test, when the background of the introduction of neostigmine (inhibits the activity of the enzyme that destroys acetylcholine) dramatically improves the patient's condition;
    • state of neuromuscular transmission, which can be verified by using a special method of functional diagnostics - electromyography;
    • Immunological laboratory studies (as determined by the titer of antibodies to acetylcholine receptors and muscle protein).


    Medication or surgery

    Treatment of myasthenia reduced to replenishmissing acetylcholine (appointed by drugs that inhibit the activity of the enzyme that destroys atsitilholin such as Neostigmine) and suppression of the autoimmune process (steroid hormones and drugs that suppress the immune cell). Treatment myasthenic crises is carried out only in the hospital, sometimes in intensive care unit.

    When a progressive form of myasthenia heldsurgery - remove the thymus gland. The best results are in the case, if the operation was carried out in the first three years after onset.

    Leave a reply