What is Cushing Syndrome? What are the manifestations of Cushing's syndrome? How to treat Cushing syndrome? Answers to these questions you will find in the article.
Content
Cushing syndrome
Hypercorticism syndrome (Cushing syndrome) includes a group of diseases,
which occurs a long chronic effect on the body
excessive amounts of adrenal bark hormones, regardless of
The reasons that caused an increase in the number of these hormones in the blood.
The cause of Cushing syndrome can be various states. Most often
Hypercorticism syndrome (excess formation of bark hormones
adrenal glands) is due to increased development
Adrenocorticotropic hormone pituitary gland (Izsenko-Cushing's disease). This
The hormone can be produced by microenseum pituitary or ectopied
(located not at the usual place) corticotropic. Etopal
Malignant corticotropin can be located in bronchi, testicles,
ovarian.
Less often Cushing Syndrome occurs with the primary defeat of the bark
adrenal glands (benign or malignant crust tumors
adrenal glands, hyperplasia of adrenal cortex). Hormonally active
adrenal cortex tumor called corticosterome. It produces B
blood excess glucocorticoid. At the same time due to
The overhaul of glucocorticoids in the blood is reduced
adrenocorticotropic hormone pituitary and remaining adrenal fabric
subjected to atrophic changes.
Hypercorticism syndrome may occur in the treatment of various
Diseases with the help of hormones of adrenal cortex (glucocorticoid),
If the drug is overdose. Occasionally arise unusual
Hypercorticism syndromes due to food intake or alcoholic
poisoning.
Manifestations of Cushing Syndrome
In syndrome of hypercorticism, the same manifestations arise.
Violates the exchange of proteins, fats and carbohydrates. The decay of proteins is activated,
The excess amount of free fats is formed, rises
The amount of glucose in the patient's blood, which can lead to development
Sugar diabetes.
The manifestations of Cushing's disease are due to excessive secretion of adrenal cortex hormones, primarily glucocorticoids.
The earliest sign of the disease is obesity, with typical
Deposition of fatty fiber in the field of face, neck, belly chest. Face
At the same time it looks round, moon-shaped.
- Purple blush appears on the cheeks.
- Glucocorticoids
cause an increase in appetite and change the metabolism, increasing
blood glucose level and enhanced fat.
- Limbs on the contrary become thin due to the reduction of the mass of muscle tissue.
- On the
skin in the abdomen, shoulder belt, buttocks and thighs appear
Crimson-Blue Stripes Strength - Stria. This is the result of stretching
leather with excessive deposition of fats and disruption of the exchange of protein, due to
what kind of skin is thinning and easy to stretch.
- Harves appear on the skin.
- Wounds and cuts heal slowly.
- IN
friction places in the collar area on the neck, in the abdomen, elbow
Strengthened skin coloring occurs. In these places
Melanin is postponed, the number of which increases with
The number of adrenocorticotropic hormone.
Women have girsutism (excessive extension). Appear
Hair on the upper lip, chin, chest. Excess hair growth
Women is due to the strengthening of men's genital hormones
Androgen's adrenal cortex that women also cause violations
menstrual cycle.
Men arises impotence.
First, periodic appears, then continuous increase
Arterial pressure. Gradually develops bone tissue - osteoporosis, which is first manifested by pains in bones and joints,
Then the spontaneous fractures of the ribs, limbs. Excess
Glucchorticoid causes as a violation of the formation of a protein basis
bones and strengthens calcium output from bone tissue.
Patients complain of weakness, headaches, body weight increase.
Sometimes patients with hypercorticism disease occur
Psyche. Depression appear, various sleep disorders, psychosis.
Treatment of Cushing Syndrome
The purpose of treatment is the normalization of the level of hormones of adrenal cortex in
blood. Preparations reduced hormone products in Kore
adrenal glands - Loword, Mamomit, Metapiron - for a long time
of time.
Symptomatic treatment aimed at correction
Protein and carbohydrate disorders, level normalization
blood pressure, heart failure. In the presence of
The patient has a corticoster, is made one-sided removal
adrenal gland (one-sided adrenalctomy).
