Hyperprolaktemia: manifestations and treatment


  • Hyperprolactinemia, manifestations
  • Diagnosis and treatment of hyperprolactinemia

  • Hyperprolactinemia, manifestations

    Prolactin is a hormone produced in the front
    The proportion of pituitary glands. It is a protein molecule. Prolactin B
    The human body is responsible for stimulating the formation of milk in dairy
    glaze. In addition to the pituitary, prolactin is produced by almost all tissues
    human body, but significantly less.

    Prolactin functions are not exhausted by stimulation
    lactation. Prolactin takes part in the regulation of metabolism, in
    Regulation of water-salt metabolism and immunity, in the regulation of mental
    Functions. But still all the functions of prolactin in the body have not been studied

    The content of prolactin in the body relatively
    constant and it increases dramatically during pregnancy. Education
    Prolactin has a pulsating character and increases during sleep.
    Regulation of secretion of prolactin is carried out by hypothalamus, by production
    Prolactolyiberin stimulating hormone. Products increase
    prolactin during stress, exercise, with sucking a child
    milk during sexual intercourse.

    The stimulating effect on the secretion of prolactin is oral
    Contraceptives, some drugs (antidepressants,
    Cimetidine, metoclopramide, reserpine, verapamil, estrogens, opioid
    Analgesics, cocaine).

    TO hyperprolaktemia lead:

    • Reducing the function of the thyroid gland (hypothiosis)
    • Polycystic ovarian
    • Hyperplasia of the adrenal cortex
    • renal failure
    • cirrhosis of the liver.

    An increase in prolctin secretion is characterized by syndrome
    Chiarry Frohmel, Argonza del Castillo and Forbe-Albright. But Samoa
    The resultant cause of increasing the number of prolactin in the blood is the prolactinity of the pituitary.

    Prolactinity is a benign tumor from
    Iron fabric. Exceptionally rarely prolactinomas are
    malignant. Usually prolactine small sizes from 2 to 3 mm.
    Then they are called microenomas. Occasionally there are macroenomes
    sizes more than one centimeter.

    Hyperprolaktemia: manifestations and treatment
    Women prolactinomas are found ten times
    more often than men. But men have almost all the adenomes of large sizes.
    Sometimes the reason for increasing prolactin in the blood cannot be installed,
    Such a condition is called idiopathic hyperprolactinemia.

    Long-term increase in blood prolactin causes the development of hypogonadotropic hypogonadism (reduction
    Functions of the sex glands with a reduced number of stimulating
    Gonadotropins in the blood). This is manifested by the development of infertility and
    increased risk of osteoporosis (bone resolution, which
    Increases the risk of bone fractures).

    In women, most often the main sign of the increase in blood prolactin
    It happens a galactorian (spontaneous allocation of milk milk

    In men, this is manifested by a decrease in sexual entry (libido) and the emergence of impotence.
    Sometimes men also have the release of milk from the mammary glands.
    Sometimes there can be only a selection of several drops when pressing
    on the milk gland, in other cases the milk is allocated constantly
    or periodically.

    Often in women the only complaint is the absence of menstruation or menstrual disorders of the menstrual cycle.

    Prolactin oppresses the secretion of follitropine and
    Lutropin, which stimulate the formation of estrogen in women.
    The lack of stimulating hormones and estrogen leads to a lack of
    ovulation and infertility. The lack of estrogen also leads to an increase
    body masses, fluid delay in the body and to osteoporosis. If
    This is the strengthening of androgens products, women occur
    Girsutism (excess hair growth on the body), acne.

    In men, excessive products prolactin causes loss of libido, no erection, impotence, gynecomastia
    (increase in the mammary glands). With a large prolactinity may occur
    Symptoms from the nervous system because the growing adenoma
    squeezes nearby fabrics and nerves. In this case, may occur
    violation of vision, narrowing of fields of view, violation of the function of the cranial

    Diagnosis and treatment of hyperprolactinemia

    Diagnosis of hyperprolactinemia helps to establish high blood prolactin content.

    Discover the adenoma of the pituitary gland allow computer and magnetic resonance tomography.

    Treatment of hyperprolactinemia depends on the main
    Diseases. To reduce the level of prolactin in the blood apply
    Preparations that reduce the products of the prolactin of levodopa, Parlodel, Lizuride,
    Lergotril, Peritol, Cirogeptadine. Typically treatment starts with appointment
    Parlola. It is effective in 85% of patients.

    Radiotherapy and surgical treatment applies. With large
    adenoma pituitary, which destroy the Turkish saddle, squeeze
    Spectating nerves, prolactin is removed by the operational way using microsurgery.

    The results of operational treatment are good. Prolactin level
    It is normalized very quickly in 90% of patients, in women in 2-3 months
    Regenerate menstrual cycle, Libido is restored in men
    And the Erection Indicators are improved.

    Worse than the results of treatment in patients with large adenomas.
    Radiotherapy applies as an addition to the surgical method

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