Explanation hCG assays and PAPP-A


Blood on PAPP-A in pregnancy

Explanation hCG assays and PAPP-A

PAPP-A (a portmanteau of Pregnancy Associated Plasma Protein A.), Or pregnancy-associated plasma protein A - protein normally synthesized during pregnancy fetal membranes.

Functions of PAPP-A in pregnancy:

  • stimulation of growth and differentiation of tissues;
  • regulation of immune response during pregnancy.

Indicators Papp levels during pregnancy canuse for screening and monitoring of a number of pathologies in women and fetus. For this reason, quantitative determination of PAPP-A, along with tests for AFP, hCG and estriol, is recommended for use as an obligatory study of pregnancy.

Interpretation of the results of tests for PAPP-A in pregnancy.

Unit PAPP-A levels during pregnancy - IU / ml or U / L.

The rate of PAPP-A in pregnancy:

  • Week 8 - 0.2-1.5 mU / ml;
  • 12-14 Week - 1-8,6 mU / ml.

Reducing the level of PAPP - a possible sign of the following pathologies:

  • a high risk of chromosomal disorders (Down syndrome, Edwards syndrome, and others.);
  • the threat of spontaneous abortion in the early stages;
  • developing pregnancy.

The final diagnosis is only placed by a gynecologist, and only after a series of additional tests and studies.

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