Hemosorption - is passing blood in a specialapparatus through the artificial filter consisting of synthetic materials (e.g., activated carbon) which easily absorb and precipitate the "heavy" toxin molecule. hemosorption procedure involves returning the purified blood to the patient, while toxins caused pathological process remain sorption box.
The difference of efferent therapy methods isprocedure and in the effects exerted on the body. If plasmapheresis has great immunocorrective and reokorregiruyuschim (normalization of blood flow) effect, the hemosorbtion - great detoxifying effect.
The differences are based on biophysical laws: some are toxic substances in the structure of molecules of free radicals, i.e. they are electrically charged, so can be fixed on the sorbent; but many pathological agent have a closed structure and, therefore, are electrically neutral (e.g., immune complexes, some kinds of allergens, cholesterol, and others.). Electrically neutral substances do not stay sorbent. Accordingly, in this case, a more efficient procedure is plasmapheresis, in which the plasma is removed, together with soluble complexes of pathogens therein.
After the first treatment there is a significantreduction of pathological concentrations of products, but after a few hours in the blood concentration increases and approaches the source. This is explained by the fact that in the bloodstream actively enter the substances dissolved in the tissue and cellular fluids. Remove these substances can efferent subsequent procedures, resulting, ultimately, to reduce the concentration of pathogens in the body and long-term remission (absence of symptoms of the disease) or even cure. Therefore, to achieve a stable positive effect it is recommended no fewer than 3 procedures.
The absolute indication for hemosorption remain acute poisoning.
Among the various methods of extracorporealhemocorrection hemosorption distinguish simple circuit, unnecessary expensive equipment. The main active component of the circuit is hemosorbent. This granular carbon material subjected to activation demineralization depyrogenation, hydro processing, balancing ion and sterilizing. Hemosorbent used to remove a wide range of low and medium molecular weight, the gram-negative bacterial flora and its endotoxin from the blood of patients.
Indications for hemosorption
The main indications for hemosorption are:
- withdrawal symptoms when drug addiction, substance abuse, alcoholism;
- manic and depressive states at mental diseases and conditions;
- acute poisoning hypnotic drugs, chlorine and organophosphorus compounds, alkaloids, salicylates, heavy metals.
Contraindications for hemosorption
The main contraindications for hemosorption are:
- all kinds of bleeding;
- violation of blood coagulation;
- BCC deficit;
- persistent hypotension;
- electrolyte disorders;
- hemodynamic instability;
- cardio-pulmonary insufficiency;
- severe liver and kidney function.