The concept of hypogonadism
Hypogonadism (male) - a pathological condition caused by insufficient secretion of androgens (male sex hormones).
The cause of hypogonadism - congenital hypoplasia of the sex glands, toxic, infectious, radiation of their defeat, the dysfunction of the hypothalamic-pituitary system.
The mechanism of development of hypogonadism - reducedsecretion of hormones by the testes. In primary hypogonadism directly affected breast tissue, the secondary - hypofunction of sexual glands is caused by lesions of the hypothalamic-pituitary system with reduced gonadotrophic pituitary function.
Symptoms of hypogonadism
The manifestations of hypogonadism depend on the age,which emerged disease, and the degree of hormone deficiency (the number of male sex gormnov). There are dopubertatnogo (before puberty) and post-pubertal hypogonadism form. With the defeat of the testicles before puberty develops typical eunuchoid syndrome, there is a high disproportionate growth due to delay of ossification zone growth, lengthening limbs, hypoplasia of the chest and shoulder area. Skeletal muscles are underdeveloped, subcutaneous fat is distributed on the female type. Often true gynecomastia. The skin is pale. Poor development of secondary Popov signs:
- lack of body hair on the face and body (pubic - on the female type)
- hypoplasia of the larynx
- high voice
Genitals are underdeveloped:
- small penis size
- scrotum is formed, but depigmented, without folding
- hypoplastic testicles
- the prostate gland is underdeveloped, often not detected by palpation
In secondary hypogonadism, except symptomsandrogen deficiency, obesity is often seen, are frequent symptoms of hypofunction of other endocrine glands - the thyroid, the adrenal cortex (the result of loss of tropic pituitary hormones). Sexual desire and potency available.
If the loss of testicular function occurred afterpuberty, when sexual development and the formation of the musculoskeletal system have been completed, the symptoms are less pronounced. Characterized by a decrease of the testicles, reduced body hair facial and body treatments, thinning of the skin and loss of elasticity, the development of obesity in women's type of sexual dysfunction, infertility, autonomic-vascular disorders.
Diagnosis of hypogonadism
In the diagnosis of hypogonadism used dataX-ray and laboratory studies. When hypogonadism that developed before puberty, lagging behind "bone" age of passport for several years. The content of testosterone in the blood is below normal. In primary hypogonadism - raising the level of gonadotropin in the blood, in the secondary - its decline, in some cases, their content may be within normal limits. In the analysis of the ejaculate is marked reduction in the number of active sperm, in some cases, the ejaculate can not be obtained.
Weather favorable for life. The disease is chronic, in the course of treatment fails to reduce the symptoms of androgen deficiency.