Manifestations and diagnosis of Addison's disease

How does Addison disease manifest? How to diagnose Addison's disease? Answers to these questions you will find in the article.

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How does Addison disease manifest

The author, whose name is in the title of the disease, noted the most vivid detail («Bronze leather») in the clinical picture of this ill­Caused by chronic bark failure­killires. General symptoms There are quite well known symptoms: Slowly developing general weakness, fast fatigue, asthenia, adamina, lack of appetite, nausea, vomiting, diarrhea, decrease in blood pressure, reduction of secretion of gastric juice, blood glucose, basic metabolism, etc.

Hypertension is due to elevated content­melanin and found in most patients. Pigmen­Skin tation with Addison's disease can have the most common­Different tint. Most often occurs golden brown­Waaya, bronze coloring, from where and the name of the disease­Nia. Sometimes pigmentation has a dirty-brown, earthy, lemon-yellow shade or resembles the color of the sunny tan.

It is characteristic that even the light solar tan is kept these patients up to the new holiday season. Pigmentation development can begin with short-term skin inflammation, after which there remains a persistent hyperpigmentation spot. In clinical practice, this property uses­with a diagnostic purpose: impose a mustard for immocent­Skin, and a few days after that, the painting increases. Spots can appear on any part of the body, but the open areas of the skin are more likely pigmented­Pressure and friction (loins, knees, elbows), major skin folds.

Characterized enhanced pigmentation of folds of palms and­Reviving, while the rest of their surface is not pigmented, attracting enhancement of pigmentation into physiologists­hyperticified places (nipples of breast glands,­catching organs). It is often noted hyperpigmentation in the field of postoperative and other scars, on the places of former injuries and pyrodermic foci. In patients with Addison sickness­the pigmentation of melanocytic noncesses is loss and noted by­Phenomenon of new. A number of patients have hair acquire more­Okraska.

Pigmentation of the mucous membrane of the oral cavity - an important diagnostic sign of the illness of Addison. Often pigment­Smoked mucous membranes of the rectum and vagina, significantly less often - conjunctiv. To a very rare form of pigmentation disorders in patients with Addison disease belongs to vitiligo, when depigmented spots are developing against hyper-pigmentation.

Diagnosis of Addison Disease

The diagnosis is made on the basis of the clinically listed above­Signs.

Differential diagnosis should be carried out with treason­Pigmentation due to solar tanning, thyrotoxicosis, pernicious anemia, collagenoses, pellages, chronic heavy metals, x-ray irradiation, liver cirrhosis, malignant tumors, pigment-puffy skin dystrophy, melanodermic shape of red flat linga, porphyry, etc. The mechanism for the development of hyperpigmentation in the illness of Addison is presented as a consequence of reduction in Corkos­Road hormones leading to the enhanced production of ACTH (adrenocorticotropic hormone), and with it melanocystimulating hormone.

Lack­The level of ascorbic acid in the body with ADDI disease­Sona suggests the similarity of the pathogenesis of pyig disorders­Menstimation with the disease and C-Avitaminosis. High Co­Holding copper in the blood of patients with addison disease is likely to also increase the activity of tyrosinase and lead to the effort­The synthesis of melanin.