Signs, diagnosis and treatment of prolactinism

Content

  • How prolactinoma is manifested
  • Diagnosis and treatment of prolactinism
  • Prolactinity therapy in pregnant women


  • How prolactinoma is manifested


    Signs, diagnosis and treatment of prolactinismProlactinoma - a tumor of the front lobe of the pituitary, in excess producing prolactin. This is the most common pituitary tumor (30% of all tumors).

    Dimensions may be different - from microenhane (less than 10 mm) to macromaden (more than 10 mm) with output beyond the Turkish saddle. Microenomes and macroenomes are found equally often.

    The main signs of the presence of prolactinity in women are:

    • Galactere (isolation of milk, colostrum or milk-like fluid from one or both of the thoracic glands; the galathery is the norm in the case of pregnancy and childbirth);
    • amenorrhea.

    The main signs of the presence of prolactinity in men are:

    • Galactere;
    • Reducing libido.
    In the prolactinity in women, osteoporosis may develop, as a result of the lack of estrogen. Other symptoms include weight gain, feeling of anxiety, depression, impotence in men. During macroenomes, headaches are concerned, violation of vision due to squeezing of the tumor cells of the front lobe of the pituitary.

    Diagnosis and treatment of prolactinism

    In the presence of a large tumor, the diagnosis is not difficult. X-ray examination of the pituitary gland reveals an increase in the size of the Turkish saddle, computed tomography - tumor. In the presence of microenomes, the size of the Turkish saddle is normal, and computed tomography and magnetic resonance tomography do not always show the presence of a tumor. The diagnosis is confirmed by laboratory blood studies for the amount of serum prolactin.

    In the absence of data on the pituitary adenoma, other reasons for increased prolactin production should be excluded - pregnancy, primary hypothyroidism, chronic renal failure, violation of the liver function, chest injury, reception of drugs, stimulating prolactin synthesis.

    The main method of treatment is the surgical removal of the tumor. If the operation is impossible or turned out to be ineffective, long-term treatment of bromocriptine is carried out. In patients with microennya in 90% of cases, an improvement occurs, the function of genital glands is restored, the galactorer is eliminated, the tumor dimensions decrease. In the event of ineffective, bomocriptine is used by Cabergolin (reaches). Also, along with medicinal therapy, the macroenen is ray treatment.


    Prolactinity therapy in pregnant women


    In patients with microenoma on the background of treatment with bromocriptine, menstrual cycle and fertility normalizes. It was believed that in patients pregnant after treatment with bromocriptine, during pregnancy under the influence of placental estrogen, the tumor increases, causing impairment of vision. However, the examination and observation of several hundred pregnant women showed that the growth of the tumor during pregnancy is observed very rarely. In addition, it can be stopped by resizing bromocriptine. Since bromocriptine does not affect the fruit, the drug can be taken throughout the pregnancy.

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