What is the story of Shegren Syndrome? How to diagnose and the treatment of SHEGREEN syndrome? Answers to these questions you will find in the article.
Content
From the history of the disease...
Arid desert and water drop - such emblems chose themselves societies of patients with Sogrena syndrome (Shegren). The feeling of sand in the eyes and dry mouth - the main complaints of patients with Syogrena syndrome.
Syndrome Sogrena received its name by the Syndrian Henry Sogrena
(his last name is sometimes written as Shegran). One of the most famous Swedish
Ophthalmologists were born in 1899 in a secured bourgeois family.
Since childhood, he was fond of music and reading. Music has become Henrich's Hobby on
All my life, he was not only a good pianist, but even wrote
Several small works. In the family of Heinrich was not doctors. His
The older brother began to study medicine, but suddenly died of Spanish.
Perhaps it served as the main argument in favor of the future profession
Heinrich. At the age of 20, he entered the Caroline Institute in
Stockholm. There he met his first and only love, Maria
Hellar, the daughter of the Stockholm ophthalmologist, subsequently
spouse. He studied Henry successfully and early chose a specialty, the same,
as his bride and father-in-law became an ophthalmologist. In 1929, Henry
Sogren met a patient who was bothering dryness in the eyes,
Dry mouth and joint pain. These symptoms were separate
Well known doctors.
Heinrich Sogren and French Ophthalmologist Henry
Guegerot were the first to understand the importance of such a combination of symptoms.
Long and stubbornly studied Henry dry syndrome. He scorchedly examined
Patients using difficult techniques - surface surfactants
Eye shells (cornea and conjunctivations) under a microscope and
Photographing of the tear and salivary glands. Dry syndrome was his topic
doctoral dissertation. Many leading scientists of the time reacted to
Henry's studies skeptically, as a result he did not receive the title
Associate. It was a blow. Fame to Sogrena came significantly
later. One of his work was translated into English, and immediately
Send invitations to various conferences and symposia. Well
Recognition had to wait long, so only aged 62 years
scientist assigned the title of professor. Heinrich Sogren died in 1986,
Buried in Stockholm with his wife and parents.
Syndrome Sogrena is a disease in which
The cells of the immune system penetrate the glands that produce moisture, such
Like tear, salivary glands, bartolini glands Vagina. Glands
collapsed, as a result of which they begin to allocate insufficient moisture.
Sogrena syndrome is one of the most common autoimmune
Diseases. For example, they suffer about 40,000,000 Americans. 9 out of 10
Patients - women. The average age of the disease of about 40 years. IN
50% of cases Syogrena syndrome occurs in isolation, and 50% - together
With other diseases of the connective tissue: rheumatoid arthritis,
systemic red lupus, systemic sclerodermia, polyimosit or
dermatomyositis.
The most characteristic features of the disease are dryness,
Sand feeling, Sanding and burning in the eyes, Svetuboyazn. Eyes can
Become red, in the corners during sleep crusts are formed. In Russia
Cases of untreated sogrogen syndrome, on the cornea can
Forging ulcers. On the site of the heaze, the rutter is formed that
leads to impairment of vision or even blindness.
Human has three major salivary glands: Podium, near
and subband. With sogren syndrome, they sometimes swell and
become painful, sometimes the increase in the glands may occur on
Background of fever. Dryness in the mouth interferes to talk, makes chewing and
swallowing, especially dry food, leads to the progression of caries and
gum diseases, language can crack and become painful.
Dry mouth and in the nose is the cause of violation of taste and
Smean. Dry throat leads to cough, predispoles
Bronchitis and pneumonia. Patients with Sogrena Syndrome, whose profession
associated with public speeches (teachers, speakers), in
Some cases have to go to another job. Sometimes
dryness is felt in other organs. Deals may hit the kidneys,
Gastrointestinal tract, blood vessels, lungs, liver,
pancreas and central nervous system. Many patients
Tear strong fatigue and joint pain. In patients with syndrome
Sogrena There is a predisposition to some oncological
Diseases, so the danger of getting the lymphoma increases 40 times,
Compared to other people, so all patients with this syndrome
must be carefully examined and be under constant
observation of the doctor .Each patient symptoms are individual,
It is impossible to find two identical patients. For some manifestations
diseases are weakly pronounced, such patients can not seek many years
medical care and feel relatively good. To all
Get used to. Another disease manifestations cause strong
suffering.
Diagnostics with
Indrome Sogrena (SHEGREEN)
Syogrogen syndrome is often not diagnosed. Since not all
Manifestations of the disease appear simultaneously, therapists and dentists
sometimes treat each symptom individually and do not recognize the system
Diseases. Moreover, the causes of dryness can be different, for example,
as a side effect of drug therapy (antidepressants and means,
Lowering blood pressure). From the beginning of the disease before setting
The diagnosis on average is about 6 years.
If the doctor suspected Sogrena syndrome, it can assign some blood tests. Antinuclear factor (ANF) is a group of antibodies that react with the components of the cell kernel, they are 70% of patients with sogrogen syndrome. SSA (or RO) and SSB (or LA) - also often detected with the syndrome, SSA - in 70% and SSB - in 40%. Rheumatoid factor (RF) is a test indicating a rheumatic disease, it is positive in 60-70% of patients. Increasing the rate of settlement of erythrocytes (ESO) indicates the activity of inflammation. In the Syogren syndrome, immunoglobulin G (IgG) also rises.
Therapist can also send a patient to an ophthalmologist and a dentist for additional research. Shirmer Test
allows you to measure tears products. To detect anomalous cells
On the surface of the eye use color Bengali pink. except
Investigate eye with a slit lamp. The dentist can measure
The number of saliva produced in a certain period of time.
Slying glands scintigraphy explores the function of the salivary glands, sialography - the state of their ducts. Instant diagnosis also helps biopsy
lips: with sogren syndrome small salivary glands, which
located on the inner surface of the lip, infiltrated
lymphocytes, which is visible under the microscope.
Treatment with
Indrome Sogrena (SHEGREEN)
The main doctor of the patient with Sogrena syndrome - rheumatologist. But
Eye damage and oral cavity with this disease are treated
Specialists. With dryness of the mouth, special compositions replace
saliva. In order to slow down the progression of caries, instead
Sugar should use sugar substitutes. Don't forget about
Regular cleaning of teeth and preventive visits to the dentist. Eyes
Can be protected using artificial tears (Tears Naturale, Offagel,
Vidersik, Lacrisin) and sunglasses. In some cases
Late stage of the disease The doctor may recommend a simple operation,
As a result, the lacrimal canal, and the tear longer
It remains in the eye. For nose moisturizing, special salt
Sprays. With dry skin, you can use special lotions, and at home - air humidifiers. If possible, you need to try to avoid
Air conditioners and heaters. Do not get involved in sunbathing baths,
trips to warm countries and a bath, especially sauna. With dryness
Vagina can help special lubricants, but Vaseline use
it does not follow.
Depending on the cause and severity of symptoms may be
Used non-steroidal anti-inflammatory means (for example,
Diclofenac), delagil, hormones (glucocorticoids) and immunosuppressants.
Sogrogen syndrome is a serious, but usually not deadly
Disease, if it is diagnosed on time. Most poisoned
life dryness in the eyes and mouth, but timely began treatment can
significantly slow down the development of the disease, and in most cases
also reduce its manifestations.
