DIC: treatment guidelines

Content

  • What DIC
  • Principles of treatment and prophylaxis of disseminated intravascular coagulation


  • What DIC


    DIC - is one of the mostcommon and represent a great danger for the patient type of pathology of hemostasis. In principle, it is characterized by diffuse blood clotting to thrombus. The results of these two processes are:
    • massive consumption of coagulation factors;
    • excessive activation of fibrinolysis - the process of dissolution of blood clots. The consequence of this, in turn, is the frequent occurrence of bleeding of different localization.

    Synonyms: PBC syndrome (disseminated intravascular coagulation), AFP (intravascular coagulation and fibrinolysis), hypercoagulable syndrome, consumption coagulopathy, CBC (trombogemorragichesky syndrome). Most often used in practice, the terms "DIC" and "TGS".


    DIC non-specific and universal, soCurrently, it is considered as a general biological process designed by nature for stopping bleeding vessel integrity violation, and for distinguishing diseased tissue from the whole organism.

    DIC is quite polymorphic. The wide range can vary as the severity and prevalence of the syndrome, and the speed of its development.

    The syndrome may be acute (often lightning), subacute, but can also be a latent current, ie, become chronic.

    Principles of treatment and prophylaxis of disseminated intravascular coagulation


    DIC: treatment guidelinesPatients with DIC are subject to immediate hospitalization in the intensive care unit or intensive surveillance.

    Due to the heterogeneity of the reasons expressed, leading to the development of DIC, it is not possible to give comprehensive advice on how to care for each case.

    In the treatment of DIC must adhere to the following principles:
    • complexity;
    • pathogenetic;
    • differentiation depending on the process.

    Sense of therapeutic measures is to stop intravascular thrombus formation.


    The first action must be a doctoraimed at eliminating or active treatment underlying cause of DIC. These include activities such as the use of antibiotics (broad-spectrum connectivity directed immunoglobulin), cytostatics; active antishock therapy, normalization of blood volume; delivery and etc.

    No sooner started a successful causal treatment(Therapy with the use of antibacterial drugs) can not count on saving the patient's life. Patients in need of urgent direction or transfer to intensive care unit, mandatory engagement to the treatment process and transfusion specialists in the hemostatic system pathology.

    DIC Prevention providesthe maximum reduction in the morbidity in surgical interventions, prevention and timely treatment of infectious and septic complications, the use of measures of protection against nosocomial infections, adequate and timely monitoring of the effectiveness of breathing, hemodynamics, water-electrolyte and acid-base balance, proper treatment of diseases potentially hazardous the development of DIC.

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