The problem of treatment of patients with pemphigus true tostill relevant, although after application of hormones (glucocorticoids system) mortality of patients with pemphigus dramatically decreased from 60-90% to 15-45%.
At the moment when death occursparticularly severe (malignant) stable to hormones during illness or as a result of serious complications (myocardial infarction, stroke, sepsis, gastric ulcer, diabetes, etc.).
Depending on pemphigus manifestations are divided into:
- light, in which there are limited, small skin lesions;
- moderate affect much the skin and the mucous membranes of the mouth;
- heavy, in which, along with extensive lesions of the skin and mucous membranes have comorbidities.
Treatment of pemphigus and its success largely depends on the severity of the disease.
In the acute phase of illness appoint high(Drums) dose hormones (prednisone, dexamethasone, etc.), Regardless of the location of the disease and lesions. The dose depends on the severity of the disease. The patient receives the hormones until until bubbles stop appearing, and the erosion is not completely covered with leather. Then slowly, over several months, the hormone dose is reduced to the minimum, against which the patient there is no evidence of disease. This dose is appointed for a longer period - months and years. If at this time there are signs of acute illness, maintenance dose temporarily doubles followed by a slow decline after the disappearance of symptoms of the disease. Occasionally manage to achieve the complete abolition of hormones, taking into account that the disease is exacerbated again, but so far it's pretty risky move.
In severe cases, even when usinghigh doses of hormones can not achieve the effect, it recommended the appointment of agents that suppress the immune system. Once erosion begin to overgrow the dose is reduced to a minimum, and the patient continues to take it for 2-5 months.
Trying to enhance the effect of hormones viadifferent blood purification methods, primarily, hemodialysis, as well as some other methods. Used as methods of treating local acting directly on the skin, for example, irradiation with ultraviolet rays, and the use of disinfectants and healing agents, including herbal medicine.
Pemphigus patients should be provided good care, nutrition with a high content of protein, vitamins and the limited number of common salt, liquid.