Treatment of patients with AIDS
Treatment of patients with AIDS includes the use of antiviral drugs, which inhibit the reproduction of the virus. After confirming the diagnosis define approaches to further the management of patients.
The approach to the choice of therapy should beindividual, based on the degree of risk. The decision about when to start antiretroviral therapy, should be taken depending on the risk of HIV disease progression and degree of severity of immunodeficiency. If antiretroviral therapy is initiated before the immunologic and virologic signs progressed and disease, its positive effect may be more pronounced and prolonged.
Antiviral therapy is given to patients,starting from the acute infection stage. The main principle of AIDS and treatment, as well as other viral diseases, the timely treatment of the underlying disease and its complications, especially Pneumocystis carinii pneumonia, Kaposi's sarcoma.
It is believed that treatment of opportunisticinfections, Kaposi's sarcoma in AIDS patients should be carried out sufficiently high doses of antibiotics, chemotherapeutic agents. A preferred combination. When choosing a drug, in addition to the sensitivity of the account, you must take into account the tolerance of his patients, as well as functional condition of his kidneys because of the risk of accumulation of drug in the body. The results of treatment also depends on the thoroughness of compliance with methodologies and sufficiently long duration of treatment.
At present, for the treatment of infections caused byopportunistic infections and Kaposi's sarcoma is used longer than 6 weeks of prolonged therapy. It depends on the phase diagram and disease activity.
There are a lot of recommendations andsystems that regulate the dose and route of administration, and virtually every specialist adheres to its own circuit. Usually beginning treatment with high doses of chemotherapy or other antibiotic, a combination is used, if necessary. Subsequently, patients take drugs in the basal dose as long as the activity of the process will not decrease, and will cease completely.
Despite the fairly large number ofdrugs and AIDS and methods of treatment, the results of therapy is currently very modest and may not lead to full recovery, since clinical remission characterized by a suppression of virus replication process, and in some cases a significant reduction of the morphological signs of illness, but did not complete their disappearance. Therefore, only the prevention of virus replication, probably will be able to give the body's resistance to opportunistic infections and the development of malignant tumors by restoring the functions of the immune system or replacement destroyed immune cells.
Often a complication in the treatment of AIDS and becoming"Chemical overload" drugs used in the final stage of the disease against viruses, fungi, unicellular parasites and other microorganisms. However, many patients do not die from opportunistic infections, and the toxic effect of large doses of medication.
Appropriate therapy is to createfavorable environment for the patient's psychological, timely diagnosis and treatment of primary, background, opportunistic infections, careful medical observation.