General information about the preparation
A drug was in Moscow, the All-UnionChemical-Pharmaceutical Research Institute, it is classified as derivatives of quinoxaline di-N-oxide. In 1976, he was allowed to be used in medical practice. Production of drugs involved only in the territory of the Russian Federation. Research dioksidina lasted 15 years, they have shown a wide range of antibiotic action. Available drug in a 0.5 and a 1% solution in vials containing 5 or 10 ml. Used topically, intracisternally or intravenously. This yellowish liquid that has no odor, but a bitter taste. Occurs 5% ointment, packaged in tubes or jars, 100, 50, 25, 30 grams. More Dioksidin part of the ointment called "Dioksikol" and antibacterial soap "effect."
What the properties of Dioksidin?
The drug is a synthetic antimicrobialmeans able to exert a bactericidal effect. Dioksidin selectively inhibits the formation of deoxyribonucleic acid (abbreviated as DNA) in cells of microorganisms, in no way affecting the formation of protein, ribonucleic acid (RNA). When this structure is disrupted microbial cell membranes. In the absence of drug efficacy oxygen further increases. This increased activity characteristic only quinoxaline derivative of di-N-oxide having antibacterial properties. Dioksidina succeed in the infected body to stimulate the formation of reactive oxygen species. In the treatment of burn and wound surfaces dioksidina there are no local irritation. The wound is cleaned very well, and then there is a better tissue repair. Most therapeutic efficacy of the drug is achieved in the destruction of anaerobes, which are sensitive to diatomic oxygen, they are called obligate. It destroys as aerobic bacteria, which are the originators of purulent infectious pathologies. Can treat shigellosis, salmonellosis, cholera, Pseudotuberculosis. Dioksidin research has shown that can destroy Gram-negative bacteria: Shigella, Salmonella, Neisseria, Escherichia coli, Vibrio cholerae, klepsiellu. Exhibit activity against meningococci, staphylococci, Streptococcus, Pseudomonas aeruginosa, Proteus vulgaris. In the drug found effective against the bacteria, which is considered the culprit tuberculosis, Call it tubercle bacillus.
When appointed Dioksidin?
The drug is used in surgery (neurosurgery), dentistry, urology, otolaryngology in different types and forms of purulent infection. Diseases in which appointed Dioksidin:
- lung abscess, empyema, purulent pleurisy;
- secondary purulent meningitis, Brain abscess;
- purulent mastitis. cystitis, Peritonitis, sepsis;
- cellulitis, an abscess on the skin, sores, burns, post-surgical, post-traumatic wounds (superficial and deep);
- pustules on the skin;
- inflamed wounds in osteomyelitis.
In the vein is entered only in hospitals as a backup drug for severe infections or when the low efficiency of other antibacterial drugs.
As used Dioksidin?
Topically applied formulation at a concentration of 0.1-1%. If necessary a small concentration of the solution was taken ampoule 0.5 or 1% and diluted with isotonic sodium chloride solution (sterile), or water for injection (sold in pharmacies). On the wound gently impose sterile wipes, pre-moistened with a solution. If the wounds are deep, that sometimes loosely tamponiruyut. If there is a drainage tube, the infected cavity administered from 20 to 100 ml of the drug (0.5%). Osteomyelitis wounds treated for 15 minutes, after which the bandage, wetting cloth in a more rich solution (1%). The ointment is applied to the cleansed from necrotic (dead) tissue and pus wound surface with a thin layer, and then this region bandage. If the patient tolerates the treatment, it extends from 15 to 25 days. Preparation is administered into the cavity via a catheter, drain tube or a syringe - take from 10 to 50 ml of solution in a concentration of 1%. The procedure is done once a day or two, if the drug is well tolerated, treatment may continue for 3 weeks.
When the drug ENT doctor (or pediatrician)assigned to drip into the nose, it should do so. On the vial to make a special notch nail file, and then unpack it. Fill the clean pipette solution slightly (typically 0.5% concentration) in both nostrils and drip a required amount of drug. Before the procedure, the patient should blow his nose to nose cleansed of mucus and crusts and slightly tilt the head back - so the medicine gets into the nasal cavity and are well distributed there. The drug should be poured into a clean bottle with a lid for ease of use. Or instead use cotton wool cap and close it the hole in the cartridge. Store this medication in the refrigerator should be. Pull it out should be just before the instillation. Before instillation solution to be already at room temperature. In each nostril adults should make 3 droplets and children enough 1-2 drops three times a day. Treatment is continued for 3 to 7 days. Manufacturer instructions in writing, that the drug is only for adults, but for children it intranasally doctors prescribe - no harm, for many years the use of the negative effects were detected. Recently, it even for ease of use to produce steel in bottles of 10 ml, to which is attached a dropper, to bury in the nose or ears.
But this is administered intravenously onlyin hospital with a dropper under the supervision of a health professional. It requires strict compliance with dosage control analyzes. The drug gives good positive results, but it is toxic in excess dosage, so it belongs to the drugs reserve.
Sometimes crystals drop in solutionstored in a cool place, this is normal. Then the solution must be heated in a water bath, so that all crystals are dissolved. Occasional shaking speed up the process.
Contraindications and side effects
The drug should not be used when:
- Pregnancy and breast-feeding a baby;
- violation of adrenal function;
- Children aged up to 12 years (this applies to I / O and intracavitary administration);
- individual intolerance.
When administered intravenously into the body, the study identified a number of side effects:
- rash, pyrexia, the appearance of pigmented spots on the skin when exposed to sunlight;
- headache. convulsions;
- dyspepsia, abdominal pain, chills, diarrhea, Vomiting.
Notwithstanding that adverse events have been reported in 8-10% of patients.
Good dioksidina advantage - is the absence of toxic effects on the kidneys, liver, ears.
Local treatment dioksidina generally well tolerated.
I accumulated a lot of experience with the application of dioksidinavarious purulent infections, locally it is used frequently. But intracisternally or intravenously, due to the risk of overdose and the narrow therapeutic breadth of exposure, doctors prescribe it less often, since there are many other antibioticsSafer.